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KMID : 1103720070570040315
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Journal of the Korean Society of Radiology
2007 Volume.57 No. 4 p.315 ~ p.322
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The Effect of Imaging Parameters of Diffusion Tensor Imaging on Fractional Anisotropy
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Jun Jae-Su
Ryu Seon-Young
Lee Sang-Bong
Yang Po-Song
Kim Ji-Chang
Lee Jeong-Hyun
Choi Choong-Gon
Kim Sang-Joon
Kim Hyun-Jeong
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Abstract
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Purpose: To evaluate the effect of changes of parameters of diffusion tensor imaging (DTI), including slice thickness/slice number, b-value and the direction number of a diffusion gradient on fractional anisotropy (FA).
Materials and Methods: Three groups of normal volunteers underwent brain diffusion tensor imaging with the use of three different imaging parameters as follows: a different slice thickness/slice number (6 mm/20 slices and 2.33 mm/54 slices), a different b-value (800 s/mm2/1000 s/mm2) and a different number of directions of the diffusion gradient (6 and 15 directions). The signal to noise ratio (SNR) and FA were measured by a ROI measurement at the anterior corona radiata, superior corona radiata, putamen and corpus callosum. We compared the mean SNR and FA in each group by the use of the paired T-test.
Results: The SNR decreased and the FA increased significantly according to the increase of the slice number (6 mm/20 slices vs. 2.33 mm/54 slices). The SNR of DTI with 15 diffusion gradient directions was significantly higher than DTI with six directions, without a difference of FA. There were no significant changes of the SNR and FA of DTI according to the b-value.
Conclusion: It is essential and useful in the clinical application of DTI to understand the effect of imaging parameters on FA
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KEYWORD
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Brain, Diffusion, Magnetic resonance(MR), Anisotropy
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